HPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian women

Reports describe the association between platelet activation, adhesion, and aggregation, as well polymorphisms in genes encoding membrane glycoproteins with a predisposition to coronary artery disease (CAD). This study investigates associations HPA-1, -3 C807T CAD. A cross-sectional involving 114 women who underwent angiography was performed. The CAD+ group consisted of 63 while CAD- 51 women. Hematological biochemical parameters were evaluated by electronic methods. Polymorphisms investigated PCR-RFLP PCR-SSP participants answered an epidemiological questionnaire provided anthropometric data. Blood pressure also measured. Statistical analyses performed using EpiInfo v. 7.0 software. Results showed that age, diabetes mellitus, hypertension, hyperlipidemia associated In addition, elevated glucose, TG, VLDL-c levels reduced HDL-c levels. No significant difference observed allelic genotypic distributions -3, groups. However, carriers variant 3b allele had TG sP-selectin 807T CT LDL-c Hence, our data suggest polymorphism HPA-3 increases, indirectly, risk CAD development occurrence reduces this effec.